While gearing up for the epic Duel Express tournament your player Joey is informed by Yugi that the Millennium Puzzle has been stolen along with the amazing Yumi Yugi! In the fantastic Yu-Gi-Oh! - Reshef of Destruction you must explore the town to find the missing things by challenging opponents to games where you must strategically lay your cards to defeat them all and save Yumi and the Millennium Puzzle!

Fans of this epic Nintendo Game Boy Advance title that are hankering for other great titles might also want to get into more greatness in the form of Kid Icarus - Angel Land Story, Super Mario Land 2 - 6 Golden Coins and the amazing Super Mario Land!